In Memory of Taohttp://www.cremnc.com/memsol.cgi?page=profile§ion=info&user_id=1837217 |
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Legacy Dr. Tao-Shih Hsieh has led a distinguished academic career. His career is full of discoveries and major breakthroughs. This is certainly attributed to his solid scientific training in chemistry and immense knowledge in biochemistry and biology. He is one of the first scientists to determine the free energy of DNA supercoiling, which provides the critical information for explaining the energetic coupling between DNA superhelix and double helix, as well as the roles of DNA superhelix in various DNA transactions. Throughout his scientific career, Tao has worked on and contributed to a number of research areas. However, his fascination had remained in the topoisomerase area till his last day. One of his major scientific achievements is the discovery of the first type II DNA topoisomerase in Drosophila, to which he has devoted much of his career. Using the fly as a genetic system, he has been able to elegantly dissect the biological function of the enzyme in DNA metabolism. Tao has since worked on DNA topoisomerase I, IIIa and IIIb in the same system, and again obtained incredible insight in to the critical roles of each of these enzymes in DNA metabolism. Of particular importance is latest works on topoisomerase IIIa in mitochondrial function and aging, as well as topoisomerase IIIb in genome stability, R-loop suppression and RNA topoisomerization. Tao’s amazing works on topoisomerases represent major milestones in topoisomerase research. Most memorable, though, is his dedication to science and incredible talent. Undeniably, he serves as a model scientist for us all. |
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Positions 1981-1986 Assistant Professor of Biochemistry, Duke University at Carolina; 1986-1987 Visiting Research Associate Professor of Institute of Molecular Biology, Academia Sinica, Taiwan; 1986-1993 Associate Professor of Biochemistry, Duke University; 1988 Staff Investigator of Comprehensive Cancer Center, Duke University; 1993-2013 Professor of Biochemistry, Duke University; 2009-2016 Director and Distinguished Research Fellow of Institute of Organismic and Cellular Biology, Academia Sinica; 2013- Emeritus Professor of Biochemistry, Duke University.
Honors Tumor Biology Training Program, NIH, 1977-1980; American Society for Biochemistry and Molecular Biology, 1981; American Association for the Advancement of Science, 1981; Genetics Society of America, 1981; Basil O'Conner Starter Grant, March of Dimes, 1982-1984; American Cancer Society Junior Faculty Research Award, 1982-1985; Society of Chinese Bioscientists in America, 1985; Ad hoc reviewer for Molecular Biology Study Section, NIH, 1995; Molecular Biology Study Section, NIH, 1998-2002; Advisory Committee, 2001-2009, Chair of the Advisory Committee, 2004-2009, Institute of Cellular and Organismic Biology , Academia Sinica, Taiwan; Editorial Advisory Board, Journal of Biology Chemistry, 2003-2009; Member, Molecular Genetics Study Section, NIH, 2007-2013; External Review Committee, Department of Life Science, National Taiwan University, 2008; Molecular Genetics A study section, NIH, 2009; Molecular Genetics C study section, NIH, 2007-2013; External Review Committee, Department of Chemistry, 2010, Institute of Zoology, 2011, National Taiwan University; Organizer and Co-Chair of the TOPO2011 International Meeting on DNA Topoisomerases and Chromosome Dynamics; Taiwan Academician in Academia Sinica, 2012; Elected Fellow of The World Academy of Sciences (TWAS), 2013. |
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